Abstract
The present study was undertaken to see whether the function of the pancreas in diabetics is improved by the exogenous insulin treatment. In seven diabetic patients, bonito insulin was injected every day until the urine sugar became negative, and the diurnal change of plasma insulin was estimated before insulin injection and during the urine sugar-free period. Plasma insulin area, calculated by our formula, increased in six of the patients. As bonito insulin does not show any immunological cross-reaction with pork, beef and human insulin, this increase in plasma insulin area after the bonito insulin treatment may be due to an improvement of the impaired function of the pancreas
