The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Mixed Lymphocyte-Platelet, Lymphocyte-Kidney Cell and Lymphocyte-Liver Cell Reactions in Rats
TETSURO NISHIHIRA, GENSHICHIRO FUJII
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Keywords: cultures of lymphocytes mixed with kidney cells, liver cells or platelets, organ specific antigens, transplantation immunity
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1972 Volume 108 Issue 1 Pages 1-7

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Abstract
The lymphocyte-platelet reaction (MLPR) in various donor-recipient combinations in rats showed a nearly coincident relationship with the mixed lymphocyte culture reaction (MLC). The kidney cells had not enough stimulating effect against allogeneic lymphocytes to induce blastoid transformation. The liver cells stimulated allogeneic lymphocytes to induce blastoid transformation and to increase incorporation of 3H-thymidine, and the magnitude of the mixed lymphocyte-liver cell culture reaction in various donor recipient combinations corresponded to MLC and survival time of skin allografts.
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