Abstract
The effects of Droperidol on EEGs of both cortex and hippocampus, VEP, ECG, respiration and body movement were investigated in sixteen adult albino rats. The dose administered, i. p., was graded 0.05, 0.5, 2.5, 5, 25, 50, 75 and 100mg/kg. EEGs in both cortex and hippocarnpus were stable apparently in small dose, but the regularity in cortical EEG increased according to the frequency analysis. In large dose both EEGs changed to slow rhythm superimposing fast activity and in extremely large dose they faded out. Peak latencies of the components in VEP shortened in small dose and delayed in large dose. Pulse rate increased in small dose, but decreased in large dose. Ischemic effects to ECG were found in extremely large dose. Respiratory rate was hardly affected. Body movement was calmed down. The maximum effects appeared at 15 to 60min after the medication and the effects continued for several hours, but they were well correlated with the administered dose.
