Abstract
Bursectomized and X-irradiated chickens were given intraperitoneal inoculation of live bursa cells in an attempt to restore the periellipsoidal lymphoid cells in their spleens. An injection of viable cells prepared from autologous bursae into neonatally bursectomized and X-irradiated chickens produced no recognizable restoration of the bursa-dependent lymphoid elements, i.e., periellipsoidal lymphoid cells, germinal center cells and plasma cells. A slight restorative effect was found by inoculations on the 8 th and 9 th days of a large number of homologous bursa cells, which were obtained from newly hatched or 4-week-old chickens. In the chickens which were bursectomized, X-irradiated and given their own unirradiated bursa cells at around 2 weeks of age, all the bursa-dependent elements including the periellipsoidal lymphoid cells were found considerably restored. The result shown by the 2-week-old chickens was thought to provide a circumstantial support for the concept that the periellipsoidal lymphoid cells may be one of the cell lineages stemming from the bursal lymphoid cells.
