Abstract
Changes in lipid concentration in serum and hepatic bile in patients with gallstones were investigated before and after treatment with chlorophenoxyisobutyrate (CPIB). After 14 days of CPIB treatment, there was no remarkable change in the cholesterol and phospholipid concentration in serum, while the level of serum triglycerides was much reduced. Significant increase of cholesterol concentration in hepatic bile was observed after 14 days of CPIB treatment. These results seem to indicate that CPIB has an effect to increase the cholesterol and phospholipid levels in bile. It is suggested that CPIB, an inhibitor of cholesterol synthesis in the liver, may promote excretion of cholesterol into bile from hepatic cells.
