The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Effect of Manganese on the AV Node of Dog in situ
SHIGETOSHI CHIBA, KEISUKE SATOH, KOROKU HASHIMOTO
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Keywords: AV node, MnCl2, nodal rhythm, AV block
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1973 Volume 111 Issue 4 Pages 405-406

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Abstract

MnCl2 induced negative dromotropic effect on the AV node of dogs in situ. At a dose level above 10mg, a transient AV block was observed. The injection of 1-3mg of MnCl2 suppressed the acceleration of AV nodal rhythm, which was induced by administration of 1 μg of norepinephrine.

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