The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Effects of Vitamin E on the Aggregation and the Lipid Peroxidation of Platelets Exposed to Hydrogen Peroxide
OTOTAKA HIGASHI, YOKO KIKUCHI
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キーワード: vitamin E-nicotinate, platelet aggregation, hydrogen peroxide, thrombosis, lipid peroxidation
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1974 年 112 巻 3 号 p. 271-278

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The hydrogen peroxide (H2O2)-induced platelet aggregation could be inhibited by vitamin E-nicotinate and less effectively by vitamin E-acetate. The adenosine diphosphate (ADP)-induced platelet aggregation could be slightly inhibited by vitamin E-nicotinate. The lipid peroxidation of platelet exposed to H2O2 could also be inhibited by vitamin E-nicotinate. The lipid peroxide formation associated with membrane disruption may be involved in the mechanism underlying the H2O2-induced platelet aggregation.
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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