Abstract
Blood pH, serum sodium and potassium, urinary pH, sodium, potassium and ammonia, and glutaminase I and glutaminase II activities in the kidney were studied in 10 control, 20 nephrotic, 12 aldosterone administered and 6 ammonium chloride administered rats. Urine pH of the animals with nephrosis or hyperaldosteronism ranged from 6 to 7.5, whereas that of acidosis ranged from 5.2 to 5.6. All of the experimental animal groups excreted significantly larger amounts of urine ammonia than did the control animals. The activities of glutaminase I in the cortex and glutaminase II in the medulla were elevated in the nephrotic and aldosterone administered animals. In acidotic rats increases in glutaminase I and glutaminase II activities were only noted in the cortex, and the more prominent increase was found in glutaminase I.
