The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Specific Role of Magnesium Ion in Protecting the Anticomplementary Effect of DNA in Immune Hemolysis
EIJI OKUHARA, JUNKO IGARASHI, AKIRA WAKIZAKA, TSUTOMU MATSUMOTO
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キーワード: DNA, complement fixation
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1975 年 116 巻 1 号 p. 33-37

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When a constant quantity of denatured DNA required for C'-fixation reaction was employed as the antigen, an anticomplementary action of DNA was frequently observed. In order to cope with this difficulty in the analysis of C'-fixation, the relationship between DNA, Mg2+ and C' was investigated. It was found that this phenomenon was closely related to the flexible conformation of DNA which is highly influenced by Mg2+. Further, this effect could be eliminated in the presence of 5mM MgCl2. The mechanism of the elimination by Mg2+ of the anticomplementary effect of DNA was discussed.
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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