The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Inhibition of Dopamine-β-Hydroxylase by Carnosine
HIROSHI IZUMI, MAKOTO HAYAKARI, YOSHIKAZU KONDO, TSUNEMATSU TAKEMOTO
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キーワード: dopamine-β, hydroxylase, carnosine
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1975 年 117 巻 1 号 p. 101-102

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Dopamine-β-hydroxylase was partially purified from bovine adrenal medulla and the effect of carnosine on the dopamine-β-hydroxylase activity was investigated. Carnosine significantly inhibited the enzyme activity at the concentrations higher than 0.5mM. According to the Lineweaver-Burk plots, the inhibition observed appeared to be a non-competitive type with the substrate, tyramine.
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