The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Inhibitory Substance (Substance I) in Rat Liver of Dopamine-β-Hydroxylase and Its Effect on the Rat Blood Pressure
HIROSHI IZUMI, MAKOTO HAYAKARI, YOSHIKAZU KONDO, TSUNEMATSU TAKEMOTO
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Keywords: dopamine-β-hydroxylase;substance I, vasodilatation
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1975 Volume 117 Issue 2 Pages 201-202

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Abstract
In a series of experiments undertaken to investigate the naturally occurring inhibitors of dopamine-β-hydroxylase, we extracted some active substance from rat liver. This substance was named “substance I” because of its inhibitory effect on the dopamine-β-hydroxylase. Substance I had some hypotensive effect on the rat blood pressure.
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