Abstract
The concentration of cefazolin sodium (hereinafter referred to as CEZ), a cephalosporin antibiotics, in the renal tissue, blood, and urine was measured in dogs with experimentally induced acute and chronic pyelonephritis in the left kidney. The results were as follows: The blood concentration of intravenously given CEZ, in terms of half life (T 1/2), was found to last longer than that in healthy animals. The tissue concentration in the acute mild pyelonephritic kidney was higher and lasted longer than that in the contralateral healthy kidney. The tissue concentration in the severe acute pyelonephritic and chronic pyelonephritic kidney was inversely lower than that in the healthy kidney. The urinary concentration and urinary recovery in the first 2-hr urine from the affected kidney were far lower than those from the healthy kidney, irrespective of severity or chronicity of inflammation. The findings in dogs suggest that the renal concentrations of antibiotics in patients with acute and mild pyelonephritis are higher and last longer than those in healthy persons, that the renal concentrations in patients with severe and chronic pyelonephritis are inversely lower than that in healthy persons, and that the urinary excretion of antibiotics in patients with pyelonephritis decreases as compared with that in healthy persons.
