The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Effects of Verapamil on the Contractile Force in the Glycerinated Dog Heart Muscles
YUKIO MARUYAMA, NOBUMASA ISHIDE, HIROSHI OKAYAMA, EIJI INO-OKA, TAMOTSU TAKISHIMA
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Keywords: Ca-antagonist, contractility, glycerinated heart muscle fibers, verapamil
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1979 Volume 128 Issue 2 Pages 199-200

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Abstract
The effect of Ca-antagonist on the contractile apparatus was investigated in glycerinated cardiac papillary muscle preparations obtained from canine hearts. The results showed that maximal developed tension (P0) was enhanced significantly by 5 mg/liter of verapamil, and the augmentation of contractility was dependent on the concentrations of verapamil. As a conclusion, Ca-antagonist appeared to be a potentiating agent of the contractile force on the contractile apparatus.
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