The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
The Screening Test of Various Chemotherapeutic Drugs in Primary Malignant Melanoma Cells and Human Malignant Melanoma Cell Line (TM-1)
YOSHIKI KURIYATETSURO NISHIHIRASHOZO MORITOSHIO WATANABEMORIO KASAI
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1979 Volume 128 Issue 3 Pages 209-216

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Abstract

The sensitivities to various chemotherapeutic drugs of the primary malignant melanoma cell of the esophagus and the malignant melanoma cells established from human skin were studied by determining the incoporation of 3H-thymidine into tumor cells using the tissue culture method. The incorporation of 3H-thymidine was depressed by a low concentration of Actinomycin D in malignant melanoma cells of the esophagus and by a low concentration of Adriamycin or Actinomycin D in the established malignant melanoma cells. When Actinomycin D was clinically used according to the experimental results, the subcutaneously metastasized tumor was remarkably reduced.

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