The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
The Effect of L-Asparaginase on Cholesterol Biosynthesis
TAKEO TAKEDANOBUO MATSUURA
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1981 Volume 133 Issue 3 Pages 289-291

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Abstract

TAKEDA, T. and MATSUURA, N. The Effect of L-Asparaginase on Cholesterol Biosynthesis. Tohoku J. exp. Med., 1981, 133 (3), 289-291-The liver from the Wistar rat was incubated either in the solution of 1μCi acetate-1-14C or 0.1 μCi mevalonic acid-2-14C, and incorporations of radioactivity to phospholipid and cholesterol were estimated respectively. The incorporation of labeled acetate to cholesterol in the L-asparaginase-treated rat was significantly lower than that in the controls. However, there were no differences of the incorporation into the mevalonic acid between the study group and the controls. These results suggest that the inhibitory mechanism may exist between the steps of acetate and mevalonic acid.

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