The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Probable Superoxide Therapy of Experimental Cancer with D-Penicillamine
SHINICHI OKUYAMA, HITOSHI MISHINA
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キーワード: superoxide therapy, experimental cancer, D-penicillamine
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1981 年 135 巻 2 号 p. 215-216

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OKUYAMA, S. and MISHINA, H. Probable Superoxide Therapy of Experimental Cancer with D-Penicillamine. Tohoku J. exp. Med., 1981, 135 (2), 215-216-A sublethal dose of D-penicillamine (DP) induced hyperlipoperoxidemia and hypocupremia in old rats. Treatment of cancer cells in vitro and in vivo with DP resulted in appreciable suppression of cell multiplication and a remarkable inhibition of tumor growth. Erythropoiesis did not seem to be affected by DP. The selective effect of DP seems to have resulted from the reduced superoxide dismutase activity and/or defective Mn superoxide dismutase.
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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