The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Effect of Tocopherol Deficiency on Lipid Metabolism in Arterial Wall of Spontaneously Hypertensive Rats on Normal and High Cholesterol Diets
SHUN-ICHI MURANO, KOHJI SHIRAI, NOBUO MATSUOKA, NOBUHIRO MORISAKI, NORIHIRO SASAKI, MASAKI SHINOMIYA, MASATO MIZOBUCHI, YASUSHI SAITO, AKIRA KUMAGAI
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キーワード: tocopherol deficiency, spontaneously hypertensive rats, lipoperoxide, cholesterol esterase, atherosclerosis
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1982 年 136 巻 1 号 p. 29-34

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MURANO, S., SHIRAI, K., MATSUOKA, N., MORISAKI, N., SASAKI, N., SHINOMIYA, M., MIZOBUCHI, M., SAITO, Y. and KUMAGAI, A. Effect of Tocopherol Deficiency on Lipid Metabolism in Arterial Wall of Spontaneously Hypertensive Rats on Normal and High Cholesterol Diets. Tohoku J. exp. Med., 1982, 136 (1), 29-34 Lipid metabolism in the arterial wall of spontaneously hypertensive rats (SHR) fed on tocopherol-deficient diet, high-cholesterol diet or both was studied. Serum tocopherol was greatly decreased in tocopherol-deficient SHR. Lipoperoxide, determined as thiobarbituric acid-reactive substances, was higher in tocopherol-deficient SHR than in normal SHR. Tocopherol-deficient SHR showed a decrease in acid cholesterol esterase activity, but no change in neutral cholesterol esterase, acid and neutral lipase, acyl CoA synthetase, cytidine-diphosphate choline-1-2-diacyl glycerol choline phosphotransferase (CPT) or triglyceride synthesizing activity.
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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