Abstract
SAITO, T., YAMAKAGE, K., FURUYAMA, T. and YOSHINAGA, K. Persistent Nephrotic Syndrome and Focal Glomerular Sclerosis Produced in Rats by Aminonucleoside and Protamine. Tohoku J. exp. Med., 1982, 138 (1), 117-118 Aminonucleoside of puromycin (AN) is known to produce nephrotic syndrome in rats. Protamine sulfate (Ps) enhanced the effect of AN. So we tried in rats four series of repeated administration of Ps in combination with AN at a reduced dose. The animals developed nephrotic syndrome and without debilitation kept it for a long time. Their kidneys demonstrated an abundance of focal glomerular sclerosis, accompanied by a notable interstitial proliferation.
