抄録
MISHINA, T., WATANABE, H., FUJIWARA, T., KOBAYASHI, T., MAEGAWA, M., NAKAO, M. and NAKAGAWA, S. Immunochemotherapy for Advanced Bladder Cancer Using FT-207, Adriamycin and OK-432. Tohoku J. exp. Med., 1982, 138 (2), 161-165-A combination therapy consisting of daily intrarectal administration of 1, 500mg of FT-207 suppository, daily or every three day bladder instillation of 40mg adriamycin for a total of 20 applications, and once per week intramuscular administration of 5 KE OK-432 was described. The therapy was performed in 30 cases of advanced bladder cancer. The effectiveness evaluated by Karnofsky's criteria was as follows: 8 cases of 0-0, 2 of 0-A, 1 of 0-B, 2 of 0-C, 7 of 1-A and 10 of 1-B, showing an effective rate of 57%. Local pain was observed in 20 cases (67%), pancytopenia in 1 (3%), hepatitis in 4 (13%), stomatitis in 5 (17%) and anorexia in 6 (20%). From this clinical trial, it is presumed that combination therapy administering FT-207 intrarectally, adriamycin intravesically and OK-432 intramuscularly might be used for the treatment of advanced bladder cancer provided sufficient care is taken of general side effects.
