Comparative Studies on the Serum Levels of α-1-Antitrypsin and α-Macroglobulin in Several Mammals

Abstract

TAKAHARA, H., NAKAMURA, Y., YAMAMOTO, K. and SINOHARA, H. Comparative Studies on the Serum Levels of α-1-Antitrypsin and α-Macroglobulin in Several Mammals. Tohoku J. exp. Med., 1983, 139 (3), 265-270 -The sera of human, cattle, horse, sheep, goat, pig, dog, rabbit, guinea pig, rat, hamster, and mouse were assayed for total trypsin-inhibiting capacity, and for concentrations of α-1-antitrypsin and α-macroglobulin. The rodents examined showed striking species differences: the α-1-antitrypsin levels of mouse, rat, and guinea pig were more than twice the human level, while the α-macroglobulin levels of hamster and guinea pig were 340 and 40%, respectively, of the human level. On the other hand, little variations were found among the large domestic animals, their levels of the two inhibitors being similar to those of the human.