Abstract
The cava pocket blood sample of rabbits was taken at various stages of pregnancy, and was tested against adrenalin chloride of the Sankyo Co. by means of the rabbit intestine strip method and the paradoxical eye reaction in parallel. From the suprarenals left behind in the cava pocket experiment the acid extract was prepared and also tested by both the biological methods and the colorimetrical method of Folin, Cannon and Denis.
While the suprarenal vein blood of the non-pregnant rabbit involves a greater ability of dilating the denervated pupil than of inhibiting the rabbit intestine movement, the pregnancy alters the ability, and this becomes remarkable with the advancement of the same, the ratio of the value obtainable by the denervated pupil to that by the rabbit intestine being recorded as 1:1.5 in this stage on an average against the average of 2.2:1 for the non-pregnant rabbit. The ratio becomes reverse.
In respect of the ratio of the values obtained by both biological methods, the suprarenal vein blood and the extract of the suprarenal gland left behind after the cava pocket experiment show a reciprocal relation; it is readily intelligible when it is taken into consideration that the over-seeretion of a substance can act to diminish its storage in the gland.
