1983 Volume 140 Issue 4 Pages 429-434
TSUCHIYA, S., YAMAGUCHI, Y., KOBAYASHI, Y., MINEGISHI, M., IMAIZUMI, M., SUZUKI, H., KONNO, T. and TADA, K. An Epstein-Barr Virus-Negative B Lymphoma Cell Line (THP-2) from a Burkitt's Lymphoma of a Japanese Patient. Tohoku J. exp. Med., 1983, 140 (4), 429-434 - An Esptein-Barr virus-negative lymphoma cell line, THP-2, was established from a Burkitt's lymphoma taken from a Japanese patient. THP-2 cells grew in single cell suspension with a doubling time of 24hr; the cells carried surface-bound μ-λ immunoglobulins and formed rosettes with IgG antibody-coated ox erythrocytes. THP-2 cells expressed B1, common acute lymphoblastic leukemia (ALL) (J5) and Ia-like antigens of their surface as defined by monoclonal antibodies. Epstein-Barr virus-associated nuclear antigen (EBNA) was not detected. The cell line THP-2 has been maintained for over 5 years. Among the markers examined, only common ALL antigen has been present on the cell surface of THP-2 for these 5 years.
