Abstract
MORISAKI, N., MATSUOKA, N., SAITO, Y. and KUMAGAI, A. Effects of Pantethine and Its Metabolites on Fatty Acid Oxidation in Rat Liver Mitochondria. Tohoku J. exp. Med., 1983, 141 (1), 33-39 - The mechanism of the activating effect of pantethine [D-bis-(N-pantothenyl-β-aminoethyl) disulfide] on fatty acid oxidation was investigated in rat liver mitochondria. Pantethine, pantetheine and 4'-phosphopantetheine activated three steps of fatty acid oxidation, i.e., acyl-CoA synthetase, carnitine acyltransferase and intramitochondrial oxidation, to various extents. Although their effects may have been partly due to CoASH derived from them, they also had specific effects.
