Abstract
MORISAKI, N., SHINOMIYA, M., MATSUOKA, N., SAITO, Y. and KUMAGAI, A. In Vivo Effects of Cis-5, 8, 11, 14, 17-20:5 (n-3) and Cis-4, 7, 10, 13, 16, 19-22:6 (n-3) on Serum Lipoproteins, Platelet Aggregation, and Lipid Metabolism in the Aorta of Rats. Tohoku J. exp. Med., 1983, 141 (4), 397-405 -Highly purified cis-5, 8, 11, 14, 17-20:5 (n-3) or cis-4, 7, 10, 13, 16, 19-22:6(n-3) was administered to rats for 2 weeks, and serum lipoprotein lipid levels, platelet aggregation, and lipid metabolism in the aorta in vivo were investigated. 20:5 (n-3) decreased the level of low density lipoprotein phospholipid. 22:6 (n-3) increased the level of high density lipoprotein cholesterol and decreased those of low density lipoprotein triglyceride and phospholipid. Both 20:5 (n-3) and 22:6 (n-3) markedly inhibited platelet aggreation. 20:5 (n-3) decreased the acid and neutral cholesterol esterase activities, but did not affect either acyl-CoA synthetase or acyl-CoA: cholesterol acyltransferase activity. 22:6 (n-3) had no effect on any of these enzyme activities. From these results, the roles of 20:5 (n-3) and 22:6 (n-3) in the formation of atheromatous lesions and the mechanism of the decrease in cholesterol esterase activity by 20:5 (n-3) were discussed.
