Abstract
FUKUSHIMA, Y., MIURA, I., TAKAHASHI, T., FUKUDA, M., YOSHIDA, K., YAMAGUCHI, A. and MIURA, A.B. Serum Erythropoietin (ESF) Levels and Erythroid Progenitors (CPU-Es) of Patients with Chronic Myeloproliferative Disorders. Tohoku J. exp. Med., 1984, 142 (4), 399-407 - Serum erythropoietin (ESF) levels and the numbers of marrow and blood erythroid progenitors (CFU-Es) of patients with chronic myeloproliferative disorders (CMPD) were studied simultaneously. The numbers of marrow and blood CFU-Es per 1×105 cells were normal or greatly elevated. There was an inverse correlation between the hemoglobin concentration and the serum ESF level in patients with chronic myelogenous leukemia when the hemoglobin concentration ranged from 9.0 to 13.0g/100 ml. The serum ESF level was closely related to the hemoglobin concentration in CMPD and it was suggested that the negative feedback mechanism might operate in anemic patients with CMPD. - chronic myeloproliferative disorders; fetal mouse liver cell assay; erythroid progenitor (CFU-E); erythropoietin (ESF)
