Successful Treatment of the Crisis of Scleroderma with Enalapril Maleate (MK-421)

Abstract

OGAWA, K., KUROSE, T., KUWAHARA, T., ISHIKAWA, K., MATSUNAGA, M., NAKAMURA, Y., PAK, C.H., HARA, A. and KAWAI, C. Successful Treatment of the Crisis of Scleroderma by Enalapril Maleate (MK-421). Tohoku J. exp. Med., 1984, 144 (4), 433-434 - A 74-year-old man has been known to have scleroderma for 5 years. Two months before the hospitalization, his blood pressure was rapidly elevated, and progressive renal impairment and ulcerations of the fingers manifested. Then he was diagnosed to have a crisis of scleroderma. The treatment with a new long-acting angiotensin I converting enzyme inhibitor, enalapril maleate (MK-421), normalized the blood pressure and protected the progress of renal impairment without side effects.