The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Effects of Methylmercuric Chloride and Bis (Methylmercuric) Selenide on Responses of Isolated Intestinal Smooth Muscle of the Guinea-Pig
YASUE FUKUSHI, REIKO YAMAMOTO
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キーワード: methylmercuric chloride (MMC), bis (methylmercuric) selenide (BMS), guinea-pig taenia coli
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1985 年 145 巻 3 号 p. 243-249

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FUKUSHI, Y. and YAMAMOTO, R. Effects of Methylmercuric Chloride and Bis (Methylmercuric) Selenide on Responses of Isolated Intestinal Smooth Muscle of the Guinea-Pig. Tohoku J. exp. Med., 1985, 145(3), 243-249 - The neurologically toxic substance, methylmercury, is detoxicated by simultaneous application of selenite. In vivo formation of bis (methylmercuric) selenide has been suggested as the mechanism of detoxication by selenite. By using isolated guinea-pig taenia coli preparations, the effects of methylmercuric chloride and bis (methylmercuric) selenide on contractile responses to nerve and direct stimulation were investigated. Application of either drugs scarcely affected contractile responses to direct stimulation. However, contractile responses to nerve stimulation were severely reduced by methylmercuric chloride. The effect of bis (methylmercuric) selenide was considerably weaker than methylmercuric chloride. The site blocked by methylmercuric chloride and bis (methylmercuric) selenide in the taenia preparation was discussed
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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