The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Effect of Intracerebroventricular Injection of Vasoactive Intestinal Polypeptide on Systemic Blood Pressure, and Pancreatic and Gastric Secretions in the Rat
KAZUHIKO MIZUTA, MOTOYUKI MORIGA, HIROAKI NARUSAWA, HARUTO UCHINO, MITSURU AONO
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Keywords: VIP, blood pressure, pancreatic secretion, gastric secretion
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1986 Volume 148 Issue 1 Pages 115-116

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Abstract
MIZUTA, K., MORIGA, M., NARUSAWA, H., UCHINO, H. and AONO, M. Effect of Intracerebroventricular Injection of Vasoactive Intestinal Polypeptide on Systemic Blood Pressure, and Pancreatic and Gastric Secretions in the Rat. Tohoku J. exp. Med., 1986, 148 (1), 115-116 - In order to examine the central effects of VIP (vasoactive intestinal polypeptide) on systemic blood pressure, and pancreatic and gastric secretions in rats, the peptide was given to rats intracerebroventricularly (i. c.v.) through the lateral cerebroventricle. VIP, when given i.c.v., showed no effects on systemic blood pressure, and pancreatic and gastric secretions in rats. The present results indicate that VIP affects these functions not centrally but peripherally. Physiological role of VIP in the brain remains to be elucidated.
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