Coronary Dilator Effect of MCI-176, a New Calcium Channel Blocker, in Dogs

Abstract

HORII, D. and ISHIBASHI, A. Coronary Dilator Effect of MCI-176, a New Calcium Channel Blocker, in Dogs. Tohoku J. exp. Med., 1986, 150 (1), 101-102 -Effects of MCI-176, 2-(2, 5-dimethoxyphenylmethyl)-3-(2-dimethyl-aminoethy1)-6-isopropoxy-4 (3H)-quinazolinone hydrochloride, on coronary and aortic blood flows, mean blood pressure and heart rate were investigated in comparison with those of diltiazem in anesthetized dogs. MCI-176, like diltiazem, dose-dependently increased coronary and aortic blood flows and decreased mean blood pressure. In producing these effect MCI-176 was slightly but significantly more potent than diltiazem. Heart rate tended to increase with MCI-176, whereas it tended to decrease with diltiazem.