抄録
FUNAKOSHI, A., SHINOZAKI, H., MIYAZAKI, K., NAKANO, I. and IBAYASHI, H. Effects of Cisapride on the Secretion of Pancreatic Polypeptide in Healthy Volunteers. Tohoku J. exp. Med., 1986, 150 (2), 155-160-Plasma human pancreatic polypeptide (hPP) responses to intravenous injections of a new gastric and intestinal motility promoting agent. R51 619 (cisapride), were studied in healthy volunteers. The mean fasting concentrations of plasma hPP (39±5.4pg/ml; mean± S.E.) were elevated significantly to the peak values of 118±25.1pg/ml 30min after the drug had been given in a dose of 4mg over 5min. However, plasma insulin (IRI), glucose and prolactin levels were not elevated. Atropine diminished the cisapride-induced hPP elevation, thereby suggesting that cisapride induced release of acetylcholine but had no antidopaminergic action.
