SATO, H., ITO, M., ABE, T., KUMANO, N., MOTOMIYA, M. and KONNO, K. Antitumor Activity of Lipopolysaccharide in Tumor-Bearing Mice Pretreated with BCG. Tohoku J. exp. Med., 1986, 150 (4), 391-399-The antitumor activity of lipopolysaccharide (LPS) was investigated in BCG-treated mice. C3H/He mice and CDF1 mice were injected with BCG and then were inoculated with syngeneic mouse hepatoma MH134 and mastocytoma P815 respectively. Hemorrhagic necrosis and retarded growth of tumor were observed after an intravenous (i.v.) injection of LPS, when tumor cells had been inoculated subcutaneously (s.c.). However an intraperitoneal (i.p.) injection of BCG plus LPS did not increase the mean survival time of mice that had been inoculated with tumor cells i.p. Sera from mice that had been treated with BCG plus LPS i.v. were cytotoxic for cultured tumor cells. These results seemed to indicate that growth-inhibitoryeffects of LPS on tumors inoculated s.c. were mediated by a humoral factor.
- Nonpeptide Arginine Vasopressin Antagonists for Both V1A and V2 Receptors : Synthesis and Pharmacological Properties of 2-Phenyl-4'-[(2, 3, 4, 5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]benzanilide Derivatives
- The Occurrence of Marker Cells in Fetal Hematopoiesis of Beige (Chédiak-Higashi) Mouse
- A Study on the Mechanism of Anemia and Leukopenia in Liver Cirrhosis
- Subsequent Progression to Membranous Glomerulonephritis Following Exacerbation of Urticarial Rash in Systemic Lupus Erythematosus: Report of 2 Cases
- Natural Killer Cells in Dilated Cardiomyopathy
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The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology. - Submitted manuscripts will be screened for
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