The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Trimethoprim Interference in Methotrexate Assay by an Enzyme Inhibition Assay Kit
SETSUKO KITAOKA, MASAHIKO TERASAWA, EISUKE GOTO, TATSUO MIYAJI, SHIGERU TSUCHIYA, TASUKE KONNO
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Keywords: methotrexate, trimethoprim, methotrexate assay kit
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1986 Volume 150 Issue 4 Pages 481-482

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Abstract
KITAOKA, S., TERASAWA, M., GOTO, E., MIYAJI, T., TSUCHIYA, S. and KONNO, T. Trimethoprim Interference in Methotrexate Assay by an Enzyme Inhibition Assay Kit. Tohoku J. exp. Med., 1986, 150 (4), 481-482-Spurious methotrexate (MTX) concentrations in sera and cerebrospinal fluids from leukemia patients who were given trimethoprim (TMP) were estimated using an MTX assay kit which is based on its inhibition of dihydrofolate reductase. The interference of TMP with MTX was confirmed in the assay system. A concentration of 0.17μg/ml of TMP gave a value for an apparent MTX of 10μM.
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