Antiarrhythmic Effects of a Novel Diamine Derivative, AN-132, on Several Animal Models of Cardiac Arrhythmias

Abstract

SAKAI, K., YAMAZAKI, T. and TAKAGI, M. Antiarrhythmic Effects of a Novel Diamine Derivative, AN-132, on Several Animal Models of Cardiac Arrhythmias. Tohoku J. exp. Med., 1987, 151 (4), 443-451 - The antiarrhythmic activities of AN-132, 3-(diisopropylaminoethylamino)-2', 6'-dimethylpropionanilide•2H₃PO₄, compared with three reference drugs, were examined in several arrhythmic models of rats, guinea-pigs and dogs. When compared on a weight basis, AN-132 given in oral or i.v. route proved to be more potent and longer-acting than disopyramide, propaphenone and mexiletine against supraventricular and ventricular arrhythmias induced by chloroform, aconitine, ouabain and halothane-adrenaline.