Abstract
ISHIKAWA, Y., KANZAKI, T., MORISAKI, N., SAITO, Y. and YOSHIDA, S. Inhibitory Effect of FO-1561 (S-Adenosyl-L-Methionine Sulfate Tosylate) on Phospholipase A2. Tohoku J. exp. Med., 1987, 153 (3), 211-215 - The mechanism of the protective effect of FO-1561(S-adenosyl-L-methionine sulfate tosylate) on mitochonidria was investigated using rat heart muscle. FO-1561 stimulated CO2 production from palmitic acid in the mitochondria, indicating an increase in energy production. FO-1561 inhibited mitochondrial swelling induced by Ca2+ added exogenously or by addition of snake venom phospholipase A2. Moreover, FO-1561 inhibited phospholipase A2 activity directly. These results suggested that FO-1561 blocked mitochondrial swelling by inhibiting endogenous phospholipase A2 activity and so preventing decrease in palmitic acid oxidation.
