1988 Volume 154 Issue 4 Pages 413-414
KEITOKU, M., OKAYAMA, H., SATOH, Y., MARUYAMA, Y. and TAKISHIMA, T. Does Diffuse Intimal Thickening in Human Coronary Artery Act as a Diffusion Barrier to Endothelium-Derived Relaxing Factor? Tohoku J. exp. Med., 1988, 154 (4), 413-414-We investigated the effect of Intimal thickness in human coronary artery on the endothelium-dependent relaxation. Histamine (in the presence of cimetidine), substance P and A23187 potently relaxed arterial rings with intima thinner than 200μm. However, those relaxations diminished progressively in the artery with intimal thickness of 200-400μm, and disappeared at the thickness greater than 400μm. These results suggest that diffuse intimal thickening greater than 200μm may inhibit the diffusion of endothelium-derived relaxing factor.
