Plasma Paracetamol Concentrations Measured by Fluorescence Polarization Immunoassay and Gastric Emptying Time

Abstract

KOIZUMI, F., KAWAMURA, T., ISHIMORI, A., EBINA, H. and SATOH, M. Plasma Paracetamol Concentrations Measured by Fluorescence Polarization Immunoassay and Gastric Emptying Time. Tohoku J. exp. Med., 1988, 155 (2), 159-164 -Radionuclide labeled gastric emptying was compared with plasma paracetamol (acetaminophen) concentration measured by fluorescence polarization immunoassay. A significant correlation was found between both gastric emptying half-time of radionuclide (t_1/2) and % isotope remained in the region of the stomach and paracetamol absorption kinetic parameters. The strongest correlation was found between t_1/2 and the time required to reach the peak plasma level of paracetamol (r=0.680, p<0.01). This study indicates that simple paracetamol marker method has enabled an indirect quantitative measurement of gastric emptying by sampling at varying time intervals.