Antihypertensive Effect of NKY-722, a New Water-Soluble 1, 4-Dihydropyridine Derivative, on Conscious Spontaneously Hypertensive Rats

Abstract

OSUMI, S., MORISHITA, S., WADA, K., USUI, H., KANDA, M., MATSUI, H. and KAKEYA, N. Antihypertensive Effect of NKY-722, a New Water-Soluble 1, 4-Dihydropyridine Derivative, on Conscious Spontaneously Hypertensive Rats. Tohoku J. exp. Med., 1988, 155 (2), 205-206 - 3-(4-Allyl-1-piperazinyl)-2, 2- dimethylpropyl methyl 1, 4-dihydro-2, 6-dimethyl-4-(3-nitrophenyl)-3, 5-pyridine dicarboxylate dihydrochloride (NKY- 722) produced a dose-dependent antihypertensive effect in conscious spontaneously hypertensive rats (SHR). In this respect NKY-722 was more potent and longer-acting than nicardipine. In canine isolated mesenteric arteries, exposed to a Ca²⁺-free medium containing high K⁺, NKY-722 inhibited Ca²⁺-induced contraction in concentration-dependent manner, suggesting the calcium antagonism as the mechanism of action.