Abstract
SKOV OLSEN, P., THERKELSEN, K. and POULSEN, S.S. Effect of Omeprazole and Cimetidine on Healing of Chronic Gastric Ulcers and Gastric Acid Secretion in Rats. Tohoku J. exp. Med., 1988, 155 (4), 305-310 - The effect of omeprazole and cimetidine on healing of chronic gastric ulcers and gastric acid secretion was investigated in rats. The effect of three doses of omeprazole given orally once daily for 25 days was investigated. In controls median ulcer healing was 19.6% after 25 days. Omeprazole increased median ulcer healing from 36% at 145 μmole/kg/day to 80% at 580μmole/kg/day. Basal and pentagastrin stimulated gastric acid secretion decresed dose-dependently by nearly 90% at a dose of 580 jimole/kg/day 22-24hr after the last dose of omeprazole. Cimetidine given twice daily, in a dose that initially inhibits gastric acid secretion by 95%, reduced acid secretion by only 50% 11hr after the last dose. Median ulcer healing after treatment with cimetidine for 25 days was 41%. This study demonstrates that omeprazole has a more longacting inhibitory effect on gastric acid secretion compared to cimetidine and accelerates healing of chronic gastric ulcers dose-dependently in rats
