Changes in Arterial Norepinephrine Concentration Following Intravenous Administration in Dogs with Lung Edema

TSUTOMU IMAMURA; AKIO YASUDA; KEISUKE AMAHA

doi:10.1620/tjem.156.271

TSUTOMU IMAMURA, AKIO YASUDA, KEISUKE AMAHA

著者情報

キーワード: norepinephrine, plasma concentration, lung edema, ARDS

ジャーナルフリー

1988 年 156 巻 3 号 p. 271-277

DOI https://doi.org/10.1620/tjem.156.271

詳細

Published: 1988 Received: 1988/01/07 Available on J-STAGE: 2006/08/31 Accepted: 1988/10/07 Advance online publication: - Revised: -
訂正情報
訂正日: 2006/08/31 訂正理由: - 訂正箇所: 論文抄録訂正内容: Wrong : IMAMURA, T., YASUDA, A. and AMAHA, K. Changes in Arterial Norepinephrine Concentration Following Intravenous Administration in Dogs with Lung Edema. Tohoku J. exp. Med., 1988, 156 (3), 271-277 - Arterial concentrations of given norepinephrine (NE) were measured after bolus administration in dogs with normal lungs and in those with oleic acid-induced lung edema. In both groups, the peak NE concentration was given by blood samples taken 30sec after injection and the concentration showed a decreasing tendency thereafter. NE concentrations were always greater in the lung edema group than in the control group and a longer period was needed for NE concentrations to return to the baseline level. This delay in the clearance of NE from the circulation might reflect a diminished uptake by the pulmonary endothelium. This phenomenon may be used for the diagnosis of pulmonary endothelial injury.
Right : Arterial concentrations of given norepinephrine (NE) were measured after bolus administration in dogs with normal lungs and in those with oleic acid-induced lung edema. In both groups, the peak NE concentration was given by blood samples taken 30 sec after injection and the concentration showed a decreasing tendency thereafter. NE concentrations were always greater in the lung edema group than in the control group and a longer period was needed for NE concentrations to return to the baseline level. This delay in the clearance of NE from the circulation might reflect a diminished uptake by the pulmonary endothelium. This phenomenon may be used for the diagnosis of pulmonary endothelial injury.

訂正日: 2006/08/31 訂正理由: - 訂正箇所: 引用文献情報訂正内容: Wrong : 1) Barton, M., Lake, C.R., Rainey, T.G. & Chernow, B. (1982) Is catecholamine release pH mediated? Crit. Care Med., 10, 751-753.
2) Block, E.R. & Stalcup, S.A. (1982) Metabolic functions of the lung. Of what clinical relevance? Chest, 81, 215-223.
3) Downing, S.E. & Lee, J.C. (1980) Nervous control of the pulmonary circulation. Ann. Rev. Physiol., 42, 199-210.
4) Ebel, J.N., Gowdey, C.W. & Vane, J.R. (1971) Blood concentration of noradrenaline in the dog after intravenous administration and the effects of desipramine. Nature (Lond.), 231, 181-182.
5) Ferreira, S.H. & Vane, J.R. (1967) Half lives of peptides and amines in the circulation. Nature (Lond.), 215, 1237-1240.
6) Fishman, A.P. & Pietra, G.G. (1974) Handling of bioactive materials by the lung. New Engl. J. Med., 291, 953-959.
7) Ginn, R. & Vane, J.R. (1968) Disappearance of catecholamine from the circulation. Nature (Lond.), 219, 740-742.
8) Hughes, J., Gillis, C.N. & Bloom, F.E. (1969) The uptake and disposition of dl-norepinephrine in perfused rat lung. J. Pharmacol. exp. Ther., 169, 237-248.
9) Imaizumi, R. (1968) Catecholamine, Igaku Shoin Ltd., Tokyo. (Japanese)
10) Iversen, L.L. (1963) Uptake of noradrenaline by the isolated perfused rat heart. Brit. J. Pharmacol., 21, 523-537.
11) Iversen, L.L. (1964) The uptake of catechol amines at high perfusion concentrations in the rat isolated heart: A novel catechol amine uptake process. Brit. J. Pharmacol., 25, 18-33.
12) Iwasawa, Y., Gillis, C.N. & Aghajanian, G. (1973) Hypothermic inhibition of 5-hydroxytryptamine and norepinephrine uptake by the lung: Cellular location of amines after uptake. J. Pharmacol. exp. Ther., 186, 498-507.
13) Metting, P.J., Levin, J.A. & Samuels, J.T. (1985) Compartmental analysis of the efflux of 1-[³H] norepinephrine from isolated perfused rat lungs. J. appl. Physiol., 58, 244-250.
14) Miyazawa, T., Nakagawa, H., Hiramoto, M., Arita, K., Hiramoto, T. & Nishida, O. (1981) Ultrastructural study of the alveolar-capillary injury with pulmonary edema induced by oleic acid in dogs. Hiroshima J. med. Sci., 30, 183-190.
15) Nicholas, T.E., Strum, J.M., Angelo, L.S. & Junod, A.F. (1974) Site and mechanism of uptake of ³H-1-norepinephrine by isolated perfesed rat lungs. Circulat. Res., 35, 670-680.
16) Rorie, D.K. & Tyce, G.M. (1983) Effects of hypoxia on norepinephrine release and metabolism in dog pulmonary artery. J. appl. Physiol., 55, 750-758.
17) Sole, M.J., Drobac, M., Schwartz, M., Hussain, M.N. & Vaughan-Neil, E.F. (1979) The extraction of circulating catecholamines by the lungs in normal man and in patients with pulmonary hypertension. Circulation, 60, 160-163.

Right : 1) Barton, M., Lake, C. R., Rainey, T. G. & Chernow, B. (1982) Is catecholamine release pH mediated ? Crit. Care Med., 10, 751-753.
2) Block, E. R. & Stalcup, S. A. (1982) Metabolic functions of the lung. Of what clinical relevance ? Chest, 81, 215-223.
3) Downing, S. E. & Lee, J. C. (1980) Nervous control of the pulmonary circulation. Ann. Rev. Physiol., 42, 199-210.
4) Ebel, J. N., Gowdey, C, W. & Vane, J. R. (1971) Blood concentration of noradrenaline in the dog after intravenous administration and the effects of desipramine. Nature (Lond.), 231, 181-182.
5) Ferreira, S. H. & Vane, J. R. (1967) Half lives of peptides and amines in the circulation. Nature (Lond.), 215, 1237-1240.
6) Fishman, A. P. & Pietra, G. G. (1974) Handling of bioactive materials by the lung. New Engl. J. Med., 291, 953-959.
7) Ginn, R. & Vane, J. R. (1968) Disappearance of catecholamine from the circulation. Nature (Lond.), 219, 740-742.
8) Hughes, J., Gillis, C. N. & Bloom, F. E. (1969) The uptake and disposition of dlnorepinephrine in perfused rat lung. J. Pharmacol. exp. Ther., 169, 237-248.
9) Imaizumi, R. (1968) Catecholamine, Igaku Shoin Ltd., Tokyo. (Japanese)
10) Iversen, L. L. (1963) Uptake of noradrenaline by the isolated perfused rat heart. Brit. J. Pharmacol., 21, 523-537.
11) Iversen, L. L. (1964) The uptake of catechol amines at high perfusion concentrations in the rat isolated heart: A novel catechol amine uptake process. Brit. J. Pharmacol., 25, 18-33.
12) Iwasawa, Y., Gillis, C. N. & Aghajanian, G. (1973) Hypothermic inhibition of 5-hydroxytryptamine and norepinephrine uptake by the lung: Cellular location of amines after uptake. J. Pharmacol. exp. Ther., 186, 498-507.
13) Metting, P. J., Levin, J. A. & Samuels, J. T. (1985) Compartmental analysis of the efflux of 1-[³H] norepinephrine from isolated perfused rat lungs. J. appl. Physiol., 58, 244-250.
14) Miyazawa, T., Nakagawa, H., Hiramoto, M., Arita, K., Hiramoto, T. & Nishida, O. (1981) Ultrastructural study of the alveolar-capillary injury with pulmonary edema induced by oleic acid in dogs. Hiroshima J. med. Sci., 30, 183-190.
15) Nicholas, T. E., Strum, J. M., Angelo, L. S. & Junod, A. F. (1974) Site and mechanism of uptake of ³H-1-norepinephrine by isolated perfesed rat lungs. Circulat. Res., 35, 670-680.
16) Rorie, D. K. & Tyce, G. M. (1983) Effects of hypoxia on norepinephrine release and metabolism in dog pulmonary artery. J. appl. Physiol., 55, 750-758.
17) Sole, M. J., Drobac, M., Schwartz, M., Hussain, M. N. & Vaughan-Neil, E. F. (1979) The extraction of circulating catecholamines by the lungs in normal man and in patients with pulmonary hypertension. Circulation, 60, 160-163.

訂正日: 2006/08/31 訂正理由: - 訂正箇所: PDFファイル訂正内容: -

抄録

Arterial concentrations of given norepinephrine (NE) were measured after bolus administration in dogs with normal lungs and in those with oleic acid-induced lung edema. In both groups, the peak NE concentration was given by blood samples taken 30 sec after injection and the concentration showed a decreasing tendency thereafter. NE concentrations were always greater in the lung edema group than in the control group and a longer period was needed for NE concentrations to return to the baseline level. This delay in the clearance of NE from the circulation might reflect a diminished uptake by the pulmonary endothelium. This phenomenon may be used for the diagnosis of pulmonary endothelial injury.

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