Leukotrienes and Thromboxane B2 Stimulate Normal Human Melanocytes in Vitro: Possible Inducers of Postinflammatory Pigmentation

YASUSHI TOMITA; KAZUHISA MAEDA; HACHIRO TAGAMI

doi:10.1620/tjem.156.303

Leukotrienes and Thromboxane B₂ Stimulate Normal Human Melanocytes in Vitro: Possible Inducers of Postinflammatory Pigmentation

YASUSHI TOMITA, KAZUHISA MAEDA, HACHIRO TAGAMI

著者情報

キーワード: leukotriene C₄, leukotriene D₄, melanocyte, skin pigmentation, thromboxane B₂

ジャーナルフリー

1988 年 156 巻 3 号 p. 303-304

DOI https://doi.org/10.1620/tjem.156.303

詳細

Published: 1988 Received: 1988/10/03 Available on J-STAGE: 2006/08/31 Accepted: 1988/10/12 Advance online publication: - Revised: -
訂正情報
訂正日: 2006/08/31 訂正理由: - 訂正箇所: 論文抄録訂正内容: Wrong : TOMITA, Y., MAEDA, K. and TAGAMI, H. Leukotrienes and Thromboxane B₂ Stimulate Normal Human Melanocytes in Vitro: Possible Inducers of Postinflammatory Pigmentation. Tohoku J. exp. Med., 1988, 156 (3) 303-304 -Normal human epidermal melanocytes became swollen and more dendritiic with an increase in the amount of immunoreactive tyrosinase when they were cultured for 2 days with each one of leukotriene (LT) C₄, LTD₄ and TXB₂. Their effects were stronger than that of prostaglandin E₂, about which we have previously reported. From these data we suggest that arachidonate-derived chemical mediators, especially LTC₄, LTD₄ and TXB₂ may be responsible for the inductionn of postinflammatory hyperpigmentation of the skin.
Right : Normal human epidermal melanocytes became swollen and more dendritic with an increase in the amount of immunoreactive tyrosinase when they were cultured for 2 days with each one of leukotriene (LT) C₄, LTD₄ and TXB₂. Their effects were stronger than that of prostaglandin E₂, about which we have previously reported. From these data we suggest that arachidonate-derived chemical mediators, especially LTC₄, LTD₄ and TXB₂ may be responsible for the induction of postinflammatory hyperpigmentation of the skin.

訂正日: 2006/08/31 訂正理由: - 訂正箇所: キーワード情報訂正内容: Wrong : leukotriene C₄, leukotriene D₄, melanocyte, skin pigmentation, thromboxane B₂
Right : leukotriene C₄, leu-kotriene D₄, melanocyte, skin pigmentation, thromboxane B₂

訂正日: 2006/08/31 訂正理由: - 訂正箇所: 引用文献情報訂正内容: Wrong : 1) Nordlund, J.J., Collins, C.E. & Rheins, L.A. (1986) Prostaglandin E₂ and D₂ but not MSH stimulate the proliferation of pigment cells in the pinnal epidermis of the DBA/2 mouse. J. invest. Derm., 86, 433-437.
2) Tomita, Y., Iwamoto, M., Masuda, T. & Tagami, H. (1987) Stimulatory effect of prostaglandin E₂ on the configuration of normal human melanocytes in vitro. J. invest. Derm., 89, 299-301.

Right : 1) Nordlund, J. J., Collins, C. E. & Rheins, L. A. (1986) Prostaglandin E₂ and D₂ but not MSH stimulate the proliferation of pigment cells in the pinnal epidermis of the DBA/2 mouse. J. invest. Derm., 86, 433-437.
2) Tomita, Y., Iwamoto, M., Masuda, T. & Tagami, H. (1987) Stimulatory effect of prostaglandin E₂ on the configuration of normal human melanocytes in vitro. J. invest. Derm., 89, 299-301.

訂正日: 2006/08/31 訂正理由: - 訂正箇所: PDFファイル訂正内容: -

訂正日: 2006/08/31 訂正理由: - 訂正箇所: キーワード情報訂正内容: Wrong : leukotriene C₄, leu-kotriene D₄, melanocyte, skin pigmentation, thromboxane B₂
Right : leukotriene C₄, leukotriene D₄, melanocyte, skin pigmentation, thromboxane B₂

訂正日: 2006/08/31 訂正理由: - 訂正箇所: PDFファイル訂正内容: -

抄録

Normal human epidermal melanocytes became swollen and more dendritic with an increase in the amount of immunoreactive tyrosinase when they were cultured for 2 days with each one of leukotriene (LT) C₄, LTD₄ and TXB₂. Their effects were stronger than that of prostaglandin E₂, about which we have previously reported. From these data we suggest that arachidonate-derived chemical mediators, especially LTC₄, LTD₄ and TXB₂ may be responsible for the induction of postinflammatory hyperpigmentation of the skin.

責任著者(Corresponding author)

訂正情報

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