Erythropoietic Activity in Culture Media Conditioned by Rat Mesangial Cells

Abstract

FUKUSHIMA, Y., YANAGISAWA, M., YASUDA, T., NAKAMOTO, Y. and MIURA, A.B. Erythropoietic Activity in Culture Media Conditioned by Rat Mesangial Cells. Tohoku J. Exp. Med., 1989, 157 (2), 153-162-Using a tissue culture technique we examined erythropoietin (EPO) producing cells in rat glomeruli. In 5 out of 6 independent glomerular cell cultures, EPO activity was found in the mesangial-cell proliferating phase, but not in the epithelial-cell proliferating phase. Therefore, mesangial cells seemed to be EPO producing cells.