The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Increased Hexokinase Activity in Fetuses of Rats Developed under Maternal Hyperglycemia
YUTAKA WAKOKENICHI SUZUKIAKIHIKO ISOBESHUICHI KIMURA
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1989 Volume 159 Issue 2 Pages 139-145

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Abstract

WAKO, Y., SUZUKI, K., ISOBE, A. and KIMURA, S. Increased Hexokinase Activity in Fetuses of Rats Developed under Maternal Hyperglycemia. Tohoku J. Exp. Med., 1989, 159 (2), 139-145-Hepatic and diaphragmatic hexokinase (HK) activities increased in fetuses of rats developed under maternal hyperglycemic conditions, compared to those in normal controls. In those organs, Type I and Type II hexokinase isozymes were detected by electrophoresis and densitometry with a chromatoscanner. Densitometric peak that corresponded to hepatic and diaphragmatic Type II hexokinase was also increased in the fetuses developed under hyperglycemia, compared to that of normal fetuses. These findings suggest that in the fetal liver, where significant activity of Type IV was absent, activity of Type II hexokinase varied depending on physiological state such as maternal hyperglycemia.

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