The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Stromelysin Synthesizing Cells in the Synovial Tissues of Rheumatoid Arthritis Demonstrated by In Situ Hybridization and Immunohistochemical Methods
TAKASHI SAWAI, KAZUHIRO MURAKAMI, YOSHIHIDE OHTANI, MARKKU KURKINNEN, MASAHISA KYOGOKU, MASANDO HAYASHI
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キーワード: metalloproteinase, stromelysin, in situ hybridization, immunohistochemistry, rheumatoid arthrits
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1990 年 160 巻 3 号 p. 285-286

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SAWAI, T., MURAKAMI, K., OHTANI, Y., KURKINNEN, M., KYOGOKU, M. and HAYASHI, M. Stromelysin Synthesizing Cells in the Synovial Tissues of Rheumatoid Arthritis Demonstrated by In Situ Hybridization and Immunohisto-chemical Methods. Tohoku J. Exp. Med., 1990, 160 (3), 285-286-We identified the cells synthesizing stromelysin to be synovial cells in the synovial tissue from four biopsy cases with rheumatoid arthritis (RA) by in situ hybridization and immunohistochemical studies. In the cases which showed severe inflammation of synovia such as well developed lymphoid follicle and diffuse inflammatory infiltration, synovial cells located only in the superficial layer of synovial tissues showed abundant mRNA and enzymic protein of stromelysin.
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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