The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Vasoactive Intestinal Polypeptide Response to Ethanol in Dogs
TADASHI MISAWA, JUN ARAMAKI, YOSHIHARU CHIJIIWA, TEPPEI KABEMURA, TOSHIFUMI NASU, HAJIME NAWATA
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キーワード: VIP, mesenteric vein, ethanol, hyperosmotic saline, osmotic pressure
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1990 年 161 巻 1 号 p. 49-54

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MISAWA, T., ARAMAKI, J., CHIJIIWA, Y., KABEMURA, T., NASU, T. and NAWATA, H. Vasoactive Intestinal Polypeptide Response to Ethanol in Dogs. Tohoku J. Exp. Med., 1990, 161(1), 49-54 - Only one report has described the ethanol-induced release of vasoactive intestinal polypeptide (VIP), and its mechanism of action is unknown. We studied changes in mesenteric immunoreactive VIP (IR-VIP) concentrations following the intrajejunal administration of 100ml of normal saline, 5% and 10% ethanol, and hypertonic saline which was isoosmolar to 10% ethanol (1, 670mOsm/liter) in dogs. Administration of 5% and 10% ethanol resulted in significant and dose-dependent increases in mesenteric IR-VIP. Mesenteric IR-VIP changes and incremental integrated responses to 10% ethanol and to hypertonic saline were the same. We concluded that ethanol-induced VIP release in dogs is mainly due to ethanol's hyperosmolarity.
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