1991 Volume 164 Issue 4 Pages 259-267
FUNAUCHI, M., SUGISHIMA, H., MINODA, M. and HORIUCHI, A. Serum Level of Interferon-γ in Autoimmune Diseases. Tohoku J. Exp. Med., 1991, 164 (4), 259-267 - Interferon-γ is one of the cytokines which have various immuno-regulatory functions. In the present study, the serum interferon-γ level was determined in autoimmune diseases. It was increased in the active cases of systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD). Since there was a positive correlation between the serum interferon-γ level and the rate of peripheral mononuclear cells positive for HLA-DR antigen in systemic lupus erythematosus, circulating interferon-γ might have a biological functions as suggested by many in vitro studies. In rheumatoid arthritis and Sjögren's syndrome, there was no correlation between the serum interferon-γ level and the clinical findings. These data suggest that interferon-γ might be associated with the pathogenesis of autoimmune diseases such as SLE and MCTD, and it can be one of the indices for their disease activity.