The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Effects of Intravesically Administered Verapamil HCl(Calcium Entry Blocker) on the Bladder Function in Unanesthetized Rats
OSAMU UKIMURA, MUNEKADO KOJIMA, HIDEAKI ITOH, SHINGO HOSOI, HIROKI WATANABE
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Keywords: intravesical instillation, calcium entry blocker, verapamil HCl, bladder, rat
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1992 Volume 166 Issue 2 Pages 209-215

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Abstract

UKIMURA, O., KOJIMA, M., ITOH, H., HOSOI, S. and WATANABE, H. Effects of Intravesically Administered Verapamil HCl (Calcium Entry Blocker) on the Bladder Function in Unanesthetized Rats. Tohoku J. Exp. Med., 1992, 166 (2), 209-215-The effects of intravesically administered verapamil HCl (calcium entry blocker) on the bladder function were investigated using an experimental model for unanesthetized rats. Intravesical verapamil HCl caused a marked suppression of maximum intravesical pressure accompanied by an increase of residual urine in a dose-dependent manner. The effect almost disappeared 90min after the elimination of verapamil HCl. It is tentatively suggested that the intravesical instillation of verapamil HCl could be a potent therapy for disorders of bladder function, such as uninhibited contraction.

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