A Novel General Strategy for Cloning Tumor Suppressor Genes Using Radiation-Reduced Chromosomal Superfragments
1992 Volume 168 Issue 2 Pages 167-168
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1992 Volume 168 Issue 2 Pages 167-168
KOI, M., JOHNSON, L.A. and FEINBERG, A.P. A Novel General Strategy for Cloning Tumor Suppressor Genes Using Radiation-Reduced Chromosomal Superfragments. Tohoku J. Exp. Med., 1992, 168 (2), 167-168-To identify the tumor suppressor gene on human chromosome 11p15, we generated mouse microcell hybrids containing small transferable chromosome 11p15 fragments, which we have termed “DNA superfragments”. These hybrids will be used to identify which fragments contain a tumor suppressor gene by direct transfer of the fragments to tumor cells via microcell fusion. -DNA superfragments; tumor suppressor gene; microcell fusion
