1992 Volume 168 Issue 2 Pages 437-439
KUBOTA, K., ISHIWATA, K., YAMADA, S., KUBOTA, R., TADA, M., SATO, T. and IDO, T. Tumor Radiotherapy Monitoring with Radioscintigraphy Tracers: A Comparative Study with Multiple-Tracer Technique. Tohoku J. Exp. Med., 1992, 168 (2), 437-439 - A comparative multiple-tracer study was performed to assess the tracer feasibility of monitoring tumor radiotherapy. Metabolic tracers for glucose, amino acid, nucleic acid metabolism: F-18-FDG, C-14-Met, H-3-Thd, and F-18-FdUrd and conventional Ga-67 were compared in the same AH109A radiotherapy model using a new quadruple-tracer technique. F-18-FDG showed a large uptake change and a steady response to radiotherapy which is similar to Ga-67. F-18-FdUrd showed a rapid decrease, but the range of change in uptake was narrow. H-3-Thd and C-14-Met showed a rapid response to irradiation and a high sensitivity for monitoring radiotherapy, suggesting that if labeled with C-11, they may be feasible for PET study. - radiotherapy monitoring; tumor scintigraphy; radiopharmaceuticals
