The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
The Effect of Topical Tretinoin on the Photodamaged Skin of the Japanese
TAKAYOSHI TADAKIMARIKO WATANABEKUMIKO KUMASAKAYASUO TANITATAIZO KATOHACHIRO TAGAMIIZUMI HORIITOKIYA YOKOIYASUHISA NAKAYAMAALBERT M. KLIGMAN
Author information
JOURNAL FREE ACCESS

1993 Volume 169 Issue 2 Pages 131-139

Details
Abstract
TADAKI, T., WATANABE, M., KUMASAKA, K., TANITA, Y., KATO, T., TAGAMI, H., HORII, I., YOKOI, T., NAKAYAMYA., and KLIGMAN, A.M. The Effect of Topical Tretinoin on the Photodamaged Skin of the Japanese. Tohoku J. Exp. Med., 1993, 169 (2), 131-139 - Fifteen middle aged or elderly patients with chronic solar damage of the skin, eight patients with melasma and three patients with xeroderma pigmentosum were treated with topicial tretinoin for 6 months. There was a significant improvement in fine surface lines in periorbital region, but no significant improvement was observed in deep furrows. No significant change was induced in melasma despite the improvement in smoothness of the skin surface. Global improvement was also seen in one patient with xeroderma pigmentosum. With regard to the functions of the stratum corneum that was assessed on the flexor surface of the forearms, values of water content as well as transepidermal water loss were found to increase one month after start of the application of tretinoin cream. On the other hand, there was no significant change in the amino acid content of the stratum corneum when measured after 4 months of the treatment. It is concluded that tretinoin cream is capable of partly reversing fine surface lines in photodamaged facial skin of the Japanese. However the irritation induced by 0.1% tretinoin cream was unexpectedly severe in the Japanese as compared to that reported in Caucasians. - tretinoin; photodamaged skin; water content; transepidermal water loss
Content from these authors
© Tohoku University Medical Press
Previous article Next article
feedback
Top