Prognostic Significance of Simultaneous Infiltration of HLA-DR-Positive Dendritic Cells and Tumor Infiltrating Lymphocytes into Human Esophageal Carcinoma

抄録

FURIHATA, M., OHTSUKI, Y., SONOBE, H., ARAKI, K., OGATA, T., TOKI, T., OGOSHI, S. and TAMIYA, T. Prognostic Significance of Simultaneous Infiltration of HLA-DR-Positive Dendritic Cells and Tumor Infiltrating Lymphocytes into Human Esophageal Carcinoma. Tohoku J. Exp. Med., 1993, 169 (3), 187-195- The distribution of HLA-DR-positive dendritic cells (DR⁺DCs) and tumor infiltrating lymphocytes (TILs) was investigated in 67 patients with squamous cell carcinoma of the esophagus. DR⁺DCs were chiefly present among the cancer cell nests, and few were seen in the stroma. As clusters, UCHL-1-positive T-cells (UCHL1-Ts) were detected in the tissue around the cancer cell nests and as individual cells within tumor nests. Some UCHL1-Ts in the tumor nests showed direct contact with DR⁺DCs. In addition, a few OPD4-positive helper/inducer T cells were found among cancer cells, and were densely present in the stroma. A correlation was demonstrated between the number of DR⁺DCs and UCHL1-Ts in each patient (R=0.4547, p<0.01). In addition, dense tumor infiltration by both DR⁺DCs and UCHL1-Ts within the cancer cell nests was related to a better prognosis (p<0.01).- HLA-DR; dendritic cell; lymphocyte; esophageal cancer